GIN - Grenoble Institut des Neurosciences, ENVL
Delice aims to build a feasibility prototype for a low-flow, low-pressure fluid injection system for use on cerebral tissue. The system's potential benefits will be tested on experimental models of glioblastoma (a type of brain tumor) and cerebral thrombosis in pigs. The models will be developed at the same time as the injection technology.
For now there is no injection system precise enough to inject sufficient amounts of cancer medication into brain tumors. Delice is set to change all that. The Delice project team--drawing on CEA-Leti's extensive know-how in microelectromechanical systems (MEMS)--will develop a silicon micro-pump that meets the demanding precision and reliability requirements characteristic of this type of application. They will also overcome a major technological hurdle and incorporate sensors directly into the micro-pump to ensure maximum injection control. The team will need to design an electronic control system with power consumption low enough that the device can operate independently for several weeks. Wireless technology will be used to transfer data to and from the implants. The prototype will initially be implanted in pigs, which means also creating biocompatible packaging; the entire assembly must be sterilization resistant. Finally, to test the device the researchers will need to develop a pig glioblastoma model--a world first.